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BMS Heart Drug Camzyos Disappoints in Phase 3 Study

The ODYSSEY-HCM trial did not meet its primary endpoints.

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By: Charlie Sternberg

Associate Editor

Bristol Myers Squibb’s Phase 3 ODYSSEY-HCM trial evaluating Camzyos (mavacamten) for the treatment of adult patients with symptomatic New York Heart Association (NYHA) class II-III non-obstructive hypertrophic cardiomyopathy (nHCM) did not meet its primary endpoints. “The ODYSSEY-HCM trial, the largest and longest-duration study completed to date in patients with non-obstructive HCM, tested the hypothesis of whether a cardiac myosin inhibitor would improve measures of feel and function for th...

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